What Is It?
B-Complex Plus is an exceptional combination of
B vitamins, including vitamins B1, B2, B3, B5, B6, B12, biotin,
and folic acid, all of which are provided in their optimal
bioavailable and functional forms.*
Vitamin B6 (pyridoxine HCl and pyridoxal 5 phosphate),
supporting amino acid metabolism, nervous system
health, and neurotransmitter (i.e. GABA and serotonin)
synthesis, which studies have reported may help
promote menstrual comfort. Furthermore, pyridoxine
supports healthy red blood cells by participating in
hemoglobin synthesis and some studies indicate it
supports wrist nerve comfort.*
Vitamin B1 (thiamine HCl), processing carbohydrates,
fat, and protein via its coenzyme form of thiamine
pyrophosphate (TPP). Vitamin B1 is required to form
adenosine triphosphate (ATP), the key source of energy
for the body. Thiamine also promotes neural health.*
Vitamin B2 (riboflavin and riboflavin 5 phosphate),
metabolizing nutrients and participating in electron
transport to form ATP. Riboflavin is an integral part of
fatty acid catabolism or â-oxidation and helps convert
folic acid and vitamins B6 to their active states.*
Vitamin B3 (niacinamide and inositol hexaniacinate),
supporting cardiovascular health by mediating healthy
lipid and carbohydrate metabolism.*
Vitamin B5 (calcium pantothenate), supporting
cardiovascular health. Pantothenic acid is vital in the
healthy production, transportation, and breakdown of
lipids. Furthermore, this B vitamin promotes the
production of the neurotransmitter acetylcholine.*
Vitamin B12 (methylcobalamin), supporting healthy
nerve cell activity and DNA replication. Vitamin B12 is
a vital component of the methionine synthase
pathway, which along with folic acid and vitamin B6
supports healthy homocysteine metabolism and
S-adenosylmethionine (SAMe) production.*
Folic acid, promoting the production of healthy DNA
and chromosomes. In particular, this B vitamin is critical
for the proper neural and cellular development of the
fetal central nervous system, helping to prevent neural
tube defects. In conjunction with vitamins B12 and B6,
folic acid helps to support healthy homocysteine
metabolism. Additionally, this B vitamin is important for
the growth and reproduction of red and white blood
Biotin, acting as a coenzyme for the metabolism of fat,
carbohydrates and protein.*
Uses For B-Complex Plus
These B vitamins play important roles in nearly all of the
physiological systems in the body. Some of the key
supportive roles include the maintenance of muscle tone
in the GI tract, the functioning of the nervous system, and
the integrity of skin, hair, and the liver. Furthermore, these
compounds are essential for healthy fetal neural
development, hemoglobin formation, nerve impulse
transmissions, mood, hormone synthesis, and energy
What Is The Source?
Pure Encapsulations B-Complex Plus formula contains:
Vitamin B1 (thiamine HCl): synthetic
Vitamin B2 (riboflavin): corn dextrose fermentation
Niacinamide and Inositol hexaniacinate: synthetic
Vitamin B5 (calcium pantothenate): synthetic
Vitamin B6 (pyridoxal HCl): synthetic
Vitamin B12 (methylcobalamin): corn dextrose fermentation
Folic acid: synthetic
Vitamin C (ascorbyl palmitate) is derived from corn dextrose
fermentation and palm oil.
Pure Encapsulations recommends 1-2 capsules per day,
in divided doses with meals.
Are There Any Potential Side Effects Or
At this time, there are no known side effects or precautions.
If pregnant or lactating, consult your physician before taking
Are There Any Potential Drug Interactions?
Folic acid may adversely interact with chemotheraputic
1. Fujii A, Matsumoto H, Yamamoto H. Effect of vitamin B complex on neurotransmission
and neurite outgrowth. Gen Pharmacol 1996 Sep;27(6):995-1000.
2. Kienecker EW, Becker KW, Dick P. Modification of degenerative and
regenerative processes in peripheral nerves by treatment with B vitamins.
Klin Wochenschr 1990 Jan 19;68(2):146-8.
3. Bell IR, Edman JS, Morrow FD, Marby DW, Mirages S, Perrone G, Kayne
HL, Cole JO. B complex vitamin patterns in geriatric and young adult inpatients
with major depression. J Am Geriatr Soc 1991 Mar;39(3):252-7.
4. Hasegawa K, Mikuni N, Sakai Y. Effects of a vitamin B complex on functional
recovery after nerve injury. Nippon Yakurigaku Zasshi 1978
5. Selhub J; Jacques PF; Wilson PW; Rush D; Rosenberg IH; Vitamin status
and intake as primary determinants of homocysteinemia in an elderly population.
JAMA 1993 Dec 8;270(22):2693-8.
6. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.
each vegetable capsule contains:
thiamine HCl (B1) 100 mg.
riboflavin HCl (B2) 5 mg.
riboflavin 5' phosphate (activated B2) 10 mg.
niacinamide 100 mg.
inositol hexaniacinate (no-flush niacin) 10 mg.
pyridoxine HCl (B6) 10 mg.
pyridoxal 5' phosphate (activated B6) 10 mg.
pantothenic acid (calcium pantothenate) (B5) 100 mg.
methylcobalamin (B12) 400 mcg.
folic acid 400 mcg.**
biotin 400 mcg.
vitamin C (as ascorbyl palmitate) 16 mg.
**2 capsules provide the recommended dose for pregnant or lactating women.
12 capsules per day, in divided doses, with meals.
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