Mild or occasional anxiety is a common complaint. Herbal preparations have long
been a mainstay for maintaining a healthy, adaptive response to everyday stress and
promoting restful sleep.
Lavandula angustifolia is the most common species of lavender utilized for health
purposes.1 Lavender is native to the Mediterranean, the Arabian Peninsula, Russia and
Africa. Throughout history, lavender has been cultivated for its flowers and oils and
used both cosmetically and medicinally. Lavender has a high concentration of volatile
oils; these oils are regularly used in aromatherapy to relieve mild anxiety.* Lavender
has been also used internally for mood imbalances such as restlessness, occasional
sleeplessness, and gastrointestinal complaints related to nervousness.*2 Lavender
essential oil is obtained from steam distillation processing of the flowering tops
of L. angustifolia.
Lavela WS 1265™:
Lavela WS 1265 is an exclusive, proprietary lavender (Lavandula angustifolia) essential
oil, indicated for occasional anxiety.* Clinically shown to be comparable in efficacy to
commonly used conventional and alternative options, Lavela WS 1265 offers safe and
• Exclusive, safe and effective option
• Non-habit forming, non-sedating relief of occasional anxiety*
• Convenient, once-daily dosing
Lavela WS 1265 Clinical Overview
Several clinical studies show the benefit of Lavela WS 1265 as compared to reference
or placebo. The results were statistically significant and the response rate to treatment
Efficacy of WS® 1265
Researchers Woelk and Schläfke conducted a multi-center, double-blind, randomized
study of Lavela WS 1265 in comparison to a conventional agent for promoting
relaxation.3 The Hamilton Anxiety Rating Scale (HAMA-total score) was used as
the primary objective measurement to monitor changes in the level of tension and
relaxation beginning at baseline through week 6 of the trial. Additional data was
collected using the Self-Rating Anxiety Scale, Penn State Worry Questionnaire, SF 36
Health Survey Questionnaire and specific sections of the Clinical Global Impressions.
A total of 77 female (76.6%) and male (23.4%) subjects 18-65 years of age were
randomized into groups. Participants were eligible for the study if they met the
inclusion criteria of a HAMA-total score of greater than 18 as well as a score equal to or
greater than 2 on both anxious mood and tension items. Secondary objective outcome
data were obtained from responder and remission rate comparisons made between
the two treatment groups. In order for a participant to qualify as having a significant
response to treatment they were required to have a reduction of at least 50% in the
HAMA-total score during the six week trial. Remission was defined as a HAMA-total
score of less than ten points at the end of the six week study. The clinical results
demonstrated that WS 1265 was comparable to the conventional approach. The
HAMA-total score decreased by 45% in the WS 1265 group and decreased by 46% in
the conventional group. At the conclusion of the six week intervention, 40% of the WS
1265 group and 27% of the conventional treatment group were determined to be in
remission. The WS 1265 group had a response rate of 52.5% compared to only 40.5%
taking the conventional option. Adverse effects in the WS 1265 group were uncommon
and included nausea (5.2%), eructation (3.9%) and dyspepsia (2.6%).
Comparison to conventional options
Another study was performed to investigate the efficacy of WS 1265 in comparison
to placebo in a primary care setting.4 In 27 general and psychiatric practices, 221
adults reporting unspecified anxiety were randomized to receive 80 mg per day of
WS 1265 or placebo for 10 weeks with office visits every 2 weeks. A baseline HAMA
total score of ≥18 and a total score > 5 for the Pittsburgh Sleep Quality Index (PSQI)
were required. The primary outcome measures were HAMA and PSQI total score
decrease between baseline and week 10. Secondary efficacy measures included the
Clinical Global Impressions scale, the Zung Self-Rating Anxiety Scale, and the SF–36
(Quality of Life) Health Survey Questionnaire. Subjects taking WS 1265 showed a total
score decrease by 16.0± 8.3 points (mean± SD, 59.3%) for the HAMA and by 5.5± 4.4
points (44.7%) for the PSQI compared to 9.5± 9.1 (35.4%) and 3.8± 4.1 points (30.9%)
in the placebo group (P < 0.01 one-sided, intention to treat). WS 1265 was superior
to placebo regarding the percentage of responders (76.9 vs. 49.1%, P< 0.001) and
remitters (60.6 vs. 42.6%, P=0.009). Adverse effects were uncommon and included
dyspepsia (4.7% in the treatment group vs 1.8% in the placebo group) and eructation
(3.7% in the treatment group and none in the placebo group).
Lavela WS 1265 had a significant beneficial influence on quality and duration of sleep
and improved general mental and physical health without causing any unwanted
sedative effects.* Researchers concluded that Lavela WS 1265 was “both efficacious
and safe” for the relief of occasional anxiety not otherwise specified.* It has a clinically
demonstrable relaxing effect and was found to support restful sleep.*4
Comparison to kava and conventional alternatives
Kava kava (Piper methysticum) was among better studied herbs for supporting relaxation,
until concerns about liver toxicity prompted many companies to discontinue offering
it. In a 6-week study, kava was found to produce a mean reduction of the HAMA score
of 10 points, whereas the mean reduction of that score from WS 1265 has ranged from
11.3 points (6 week study)3 to 16 points (10 week study).4 Other conventional approaches
have mean HAMA reductions in the range of 11 to 15.3 points, suggesting comparable to
superior efficacy of WS 1265 without the side effects associated with those options.3-7
The safety profile and evaluation report for WS 1265 showed no serious adverse events
during either of the studies discussed above. Lavela WS 1265, when taken at the
recommended dose of 80 mg per day, is safe and well-tolerated, without sedative action
on the body, and no known potential for abuse.
Lavela WS 1265 offers a safe and effective solution for occassional anxiety.* It also
promotes relaxation and restful sleep.* Taken just once a day, this gentle yet powerful
botanical essential oil is non-habit-forming and well-tolerated, with efficacy demonstrated
in controlled clinical trials published in peer-reviewed medical journals.
1. Basch E, Foppa I, Liebowitz R, et al. Monograph: Lavandula angustifolia. J Herbal Pharmacother
2. Blumenthal M, ed. Lavender flower. In: The Complete German Commission E Monographs. Austin,
TX, American Botanical Council, 1998:159–60.
3. Woelk H, Schläfke S. A multi-center, double-blind, randomized study of the Lavender oil preparation
Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine 2010;17:94–9.
4. Kasper S, Gastpar M, Müller WE, et al. Silexan, an orally administered Lavandula oil
preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, doubleblind,
placebo controlled trial. Int Clin Psychopharmacol 2010;25:277–87.
5. Woelk H, Kapoula O, Lehr S, Schröter K, Weinholz P (1999). A comparison of Kava special extract WS
1490 and benzodiazepines in patients with anxiety. Healthnotes Review 6:265–70.
6. Bielski RJ, Bose A, Chang CC. A double-blind comparison of escitalopram and paroxetine in the
long-term treatment of generalized anxiety disorder. Ann Clin Psychiatry 2005 Apr-Jun;17(2):65–9.
7. Allgulander C, Hartford J, Russell J, et al. Pharmacotherapy of generalized anxiety disorder:
results of duloxetine treatment from a pooled analysis of three clinical trials. Curr Med Res Opin
2007 Jun;23(6):1245–52. Epub 2007 Apr 25.
Serving Size 1 softgel
Amount per softgel
Lavender (Lavandula angustifolia) Oil (Silexan® brand) 80 mg**
**Daily Value not established.
OTHER INGREDIENTS: canola oil, gelatin (capsule), glycerin, sorbitol, and annato extract color.
Contains no sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial flavoring, or
preservatives. This product contains natural ingredients; color variations are normal.
Recommendations: Take one softgel daily with a full glass of water, or as recommended by your
CAUTION: Not to be used during pregnancy, lactation, or by persons under 18 years of age. If
you are taking prescription medications, consult with your healthcare practitioner before using
this product. Lavender eructation has been reported in a small number of users and is a normal
effect of the product.
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