ULTIMATE RADIANCE PEPTIDE SERUM  Anti-Wrinkle  Antioxidant-Rich  Botanical Formula  “Nutrition for the Skin” • ULTIMATE RADIANCE PEPTIDE SERUM is designed to rehydrate, heal and repair both the epidermal and dermal layers of skin tissue. Provides ingredients to stimulate connective tissue repair. • ULTIMATE RADIANCE PEPTIDE SERUM contains 10% Argireline® MRP, a state-of-the art ingredient that delivers the benefits of Botox® without the side effects, discomfort and cost of expensive injections. Dramatic results can be seen in 30 days of consistent use. • ULTIMATE RADIANCE PEPTIDE SERUM contains numerous antioxidants that deactivate free radicals and help reverse the damage they cause. It also contains many nutrients essential to achieve and maintain healthy skin and a youthful appearance • ULTIMATE RADIANCE PEPTIDE SERUM combines nutrient-rich Aloe Vera with a unique natural combination of Botanicals, Vitamins, Minerals and Collagen-Boosters to create an energizing, revitalizing emollient that helps protect and repair damaged, and aging skin. • ULTIMATE RADIANCE PEPTIDE SERUM is perfect for all skin types. It’s gentle and safe to use all over the body and even around the eyes, in the ears, on lips or any sensitive skin areas. • ULTIMATE RADIANCE PEPTIDE SERUM is a high-performance formula enhanced by a delivery system created through a patented lazering technique. This technique allows for a higher concentration of nutrients and branch chained amino acids (12 timeS higher) than normally found in other skin care products. Lazering allows for immediate absorption by the skin and encourages collagen production. • ULTIMATE RADIANCE PEPTIDE SERUM is Aloe based. A skin care product has to be “delivered” where it will do the most good. Aloe Vera is an excellent delivery vehicle. Vitamin C helps increase micro-circulation and Liposome’s of Phospholipids Lecithin optimize the penetration and absorption of Tissue Respiratory Factor and Vitamins A, C and E. Background on Our Product Development Most people interested in regaining youthful skin and reducing wrinkles ask two basic questions: (1) Is it really possible to get noticeable results without huge expenses and invasive procedures? (2) If indeed wrinkles can be effectively and affordably prevented or reversed, how can one make sense out of the flood of biased commercial skin care advertisements and find out what really works and how to use it. Before deciding on the ideal wrinkle treatment, it is important to understand the difference among facial wrinkles, and their various causes. Once the underlying cause is identified then the appropriate wrinkle treatment can be applied, virtually turning back time on your skin. What is a wrinkle? The specific treatment of wrinkles is related to the cause and location of the wrinkle. Filling the wrinkle, smoothing the tissue next to the wrinkle, or weakening the muscle that causes the wrinkle are all methods to decrease skin irregularities. There are three types of wrinkles: dynamic wrinkles, static wrinkles, and wrinkle folds. DYNAMIC WRINKLES: caused by contraction of muscles attached to the overlying skin. Each muscle contraction causes the skin to bunch together, forming lines between the bulk of the muscle. The most common locations for dynamic wrinkles are between the eyebrows, across the forehead, and on the cheeks near the outer corners of the eyes, referred to as “crow’s feet”. It follows, then, that weakening these muscles will cause a reduction in the severity of the facial wrinkles, or can prevent them altogether when muscle weakening is done before wrinkles form. STATIC WRINKLES: due to lack of elasticity of the skin caused from sun damage, smoking, genetics, poor nutrition, or from prolonged dynamic wrinkling. Static facial wrinkles are visible regardless of muscle contraction; they stay (hence the name “static”) even when the muscles are not contracting. This leads to the classic “crepiness” and multiple cross-hatching as is often seen in wrinkles on the cheeks and around the eyes. Techniques that increase the thickness of the skin or that remove the damaged skin are effective wrinkle treatments. Laser skin resurfacing and deeper chemical peels remove the damaged skin and stimulate new collagen formation to improve the skin’s appearance, elasticity and thickness. WRINKLE FOLDS: due to sagging of the underlying facial structures, most notably causing the deep grooves between the nose and mouth known as the naso-labial groove. Surgical procedures such as midface lifts, cheek lifts, and neck lifts offer the best corrective measures for these problems. Alternatively, the folds can be camouflaged temporarily by plumping up the groove from beneath with substances like collagen Fat transfer, whereby your own fat is removed from one area and then injected into the area where fullness is desired, is an excellent alternative, and is one of the more permanent wrinkle treatments. Most people have a combination of all three types of facial wrinkles, especially with advanced age What causes wrinkles? GENETICS: The most common cause of wrinkles is a loss in the elasticity of the collagen layer. Collagen is a connective tissue layer that supports the outer layer of the skin (the epidermis). As we age, there is a loss of collagen elasticity and support of the overlying skin. This causes facial wrinkling. Although our genetic make-up predisposes us to have either relatively smooth or wrinkled skin, we clearly can do things to affect our skin texture, hydration, and overall health. ENVIRONMENT: There are many detrimental environmental agents that negatively affect the health of our skin. Smoking clearly decreases the microcirculation to the skin and increases the amount of facial wrinkles. Many chronic tobacco users have a marked increase in the number wrinkles around their mouth (particularly on their upper lip). Exposure to the sun or in tanning beds also decreases the elasticity of the skin, dehydrates the skin, and increases wrinkles in the skin. Harmful UVA and UVB solar rays deplete the skin of moisture and thin the dermal layer of the skin. Ultraviolet radiation also injures the cells that produce elastin and collagen fibers, causing wrinkles. It over-stimulates pigment cells, creating irregular coloring, including the brown blotches, erroneously called liver spots that appear on faces, forearms, and hands. Which Sites of Facial Lines Are Most Amenable To ULTIMATE RADIANCE PEPTIDE SERUM? ULTIMATE RADIANCE PEPTIDE SERUM is an affective anti-wrinkle treatment and skin rejuvenator for the entire face. However, it has been shown to be extremely effective on the following: Glabellas - the glabellas is the area between your eyebrows and bridge of the nose. Vertical and horizontal lines in this area are common. The presence of these lines is ageing and also may be taken to imply a person is tense or frowning. Glabellas lines are readily treated with ULTIMATE RADIANCE PEPTIDE SERUM. Forehead - horizontal forehead lines are also amenable to ULTIMATE RADIANCE PEPTIDE SERUM. These lines are also ageing and may convey the appearance of stress or surprise. Crows Feet - crows feet or laughter lines around the outside of the eye respond well to ULTIMATE RADIANCE PEPTIDE SERUM. All of these lines are due to contraction of the underlying small muscles of the face. The aim of ULTIMATE RADIANCE PEPTIDE SERUM is to weaken them so their effect on the skin is less marked. ULTIMATE RADIANCE PEPTIDE SERUM ….is all about the ingredients Extensive research has gone into the selection of every ingredient in this product for its effectiveness on skin care and its purity. Contains No Parabens The majority of skin care products on the market today contain preservatives, even those claiming to be “natural”. Methyl, Propyl, Butyl and Ethyl Paraben - all preservatives - have been know to cause allergic reactions and skin rashes. A study published in the Journal of Steroid Biochemistry and Molecular Biology (January 2002, pages 49–60) evaluated the estrogenic activity of parabens in human breast-cancer cells and implicated it to increasing breast cancer rates. Does this mean you should stop buying products that contain parabens? That’s a good question, but the answer isn’t simple or conclusive at this time, even by the standards of the study itself. Clearly it is a serious issue, and the FDA is conducting its own research to determine what this means for human health (Source: The Endocrine Disruptor Knowledge Base (EDKB), http://edkb.fda.gov/index.html). As a result, it is not contained in the product. ULTIMATE RADIANCE PEPTIDE SERUM Contains 10% Argireline® Acetyl Hexapeptide-3 (ARGIRELINE®) is a new advanced Anti-Aging Peptide and can help reduce wrinkles by inhibiting the release of catecholamines, which are known to induce the formations of wrinkles and fine lines. According to USMedicalResearch.org, “One of the most potent ingredients we have found is Acetyl Hexapeptide-3. It is used as an alternative to injections such as Botox.” Argireline is a unique new peptide that both reduces the degree of existing facial wrinkles and has been demonstrated effective against their development. It's been shown to inhibit the formation of the SNARE complex (a core of membrane proteins that mediates neuronal exocytosis) as well as catecholamine release. These inhibitions confer anti-aging activity of Acetyl Hexapeptide-3(ARGIRELINE®); they closely relate to the basic biochemical mechanisms of winkle formation. Controlled studies have also demonstrated that facial winkle depth can be reduced, especially in the forehead and around he eyes, and that Acetyl Hexapeptide-3(ARGIRELINE®) can prevent apparent facial skin ageing. Molecular mechanisms involved in facial aging include changes in collagen conformation, elastin polypeptide degradation, and problems of the skin's lipid matrix. Recent studies clearly establish that these changes can be significantly reduced by inhibiting SNARE complex formation. The Technology Acetyl Hexapeptide-3(ARGIRELINE®)'s specific sequence was shown to inhibit the SNARE complex formation and catecholamine release. Once identified, it was synthesized by solid phase peptide synthesis and then purified and characterized. Efficacy Testing In clinical testing, emulsion containing 10% of Acetyl Hexapeptide-3(ARGIRELINE®) solution was applied twice a day around eyes. It was observed that severity of wrinkles around eyes decreased up to 17% after 15 days of treatment and up to 27% after 30 days of treatment, sustaining the proposed biochemical mechanism hypothesis. ULTIMATE RADIANCE PEPTIDE SERUM Active Ingredients Glossary WHOLE LEAF ALOE VERA CONCENTRATE - Extracted from the most potent Aloe species, the Barbadensis Miller variety, Whole Leaf Aloe offers the greatest concentration of over 200 biologically active nutritional components including Polysaccharides, Vitamins, Minerals, Enzymes, Amino Acids, Growth Factors and Wound Hormones. It is concentrated by removing some of the naturally occurring water to further increase the percentage of nutritional solids. Aloe increases cell wall permeability, thereby allowing nutrients easier access while facilitating the removal of toxins. Aloe is soothing, healing, moisturizing, anti-inflammatory and may help stimulate Collagen and Elastin production. SKINTRITION™ HERBAL INFUSION - A unique combination of 8 Botanical Extracts were chosen for their individual and synergistic ability deal with both the causes of aging skin and their effects. Together, these herbs provide antioxidants, improved micro-circulation and a wide variety of the nutrients the skin requires for repair and rejuvenation. The Herbal Infusion contains: CALENDULA (Calendula officinalis) – Helpful at accelerating healing and cell turnover; gently promotes circulation; provides some anti-inflammatory activity; has enjoyed traditional use as a skin beautifying product, especially for toning the skin. Calendula flowers contain an essential oil that has an antibiotic effect and lends the flower its characteristic scent. Other components include calenden, which also has a strong odor, the carotene-like dye calendulin, the therapeutic plant fiber mucilage, saponin, organic acids, various enzymes and resins. It rapidly promotes tissue repair CHAMOMILE (Chamomilla recutita) – Has anti-inflammatory, antiseptic and anodyne properties; extracts from the flowery part of the plant are used in a variety of creams, lotions, bath oils, foam baths, shampoos and sunburn preparations for sensitive skin. It promotes the regeneration of skin cells. Chamomile preparations are ideal for treating the sensitive skin of young children who have diaper rash or other inflammatory skin conditions. Recent research points to two chamomile compounds--levomenol and azulene--as anti-inflammatory agents, while others work as antioxidants to repair damaged skin cells. Experts say that, working together, these natural ingredients can sooth skin afflicted with sunburns, eczema or allergic reactions. HORSETAIL (Equisetum arvense) – Rich in silica; helps produce new collagen fibers to regenerate connective tissue. Horsetail gives the skin a firmer, youthful and smoother look. Horsetail improves elasticity, giving skin the ability to spring back into shape. NETTLE (Urtica dioica) – Extremely rich in silica, sulfur and selenium minerals essential for healthy skin, nails and hair. Effective to help clear skin conditions. Nettle increase the microcirculation of the skin and stimulates its metabolism. It contains high amounts of soluble Vitamin C. It reduces the appearance of dark circles and wrinkles. OATSTRAW (Avena sativa) – Soothing extract that may help retard the skin’s aging process; rich in silica, sulfur and selenium. GREEN TEA EXTRACT (Camellia oleifera) – Rich source of antioxidant vitamins and bioflavonoid. It is a powerful free radical scavenger, which helps block actions of carcinogens, ultraviolet light and metastasis from an original site in the skin. Possess some antibiotic properties. WILLOW BARK (Salix alba) – Contains salicylic acid, which has multiple uses in cosmetic products including as a preservative, antimicrobial, antiseptic and fungicidal agent. It also has anti-inflammatory, antipruritic (anti-itch) and keratolytic (skin-sloughing) properties, which helps clear dead skin cells and stimulates the skin’s cell renewal process. ROSEMARY EXTRACT (Rosemarinus officinalis) – An antioxidant botanical containing several important minerals and protective, moisturizing essential oils; also possesses aromatic essential oils that offer a pleasant fragrance and helps calm and soothe irritated nerves. Other Active Ingredients: ARGIRELINE ® 10% MRP – Synthesized from the amino acids Arginine, Glutamine, Glutamic Acid, and Methionine, it delivers the benefits of Botox without the side effects. It reduces the depth of the wrinkles caused by the contraction of the muscles of facial expression, especially in the forehead and around the eyes; dramatics results can be seen in 30 days of use. L.A.Z.E.R.E.D. BRANCH CHAIN AMINO ACIDS: Branched chain amino acids consist of three aminos - L-Leucine, L- Isoleucine and L-Valine. They are one of the main components of muscle tissue. Amino acids are considered the building blocks that comprise protein and collagen. Protein gives hair and skin a protective coating, helps tissue form, and stimulates the production of antibodies. COENZYME Q10 COMPLEX (LIPOGUARD®) – This complex contains Ubiquinone (CoQ10), a powerful antioxidant supporting a natural defense against the damaging effects of free-radicals, particularly peroxidation in the skin, Vitamin E another potent antioxidant that helps the healing and water-retaining processes of the skin and Vegetable Squalene, a natural plant-derived lubricant that offers the protective benefits of mineral oils without the pore-blocking disadvantages. SODIUM HYALURONATE – This sulfated polysaccharide, shows promise as a super-moisturizer; promotes tissue growth; has exhibited some antiviral properties. BETA GLUCAN – Promotes cellular protection against UVA radiation damage; anti-erythema activity; retards the skin’s aging process. ROSE HIP SEED (ROSA MOSQUETA) OIL – Rich in Vitamin C; helps heal skin, removes blemishes, softens and moisturizes. VEGETABLE GLYCERINE – Used as a solvent, humectant and emollient in many cosmetics, it absorbs moisture from the air and therefore keeps moisture in creams and other products. Also helps products to spread better. HYDROLYZED MARINE COLLAGEN – Collagen is a protein substance found in connective tissue. These connective fibers undergo changes by time, photo-damage and other environmental challenges that contribute to the appearance of wrinkles and other outward signs of aging. Providing exogenous forms of Collagen may help reverse these effects. “Hydrolyzed” means water has been used to break down the Collagen into simpler forms for easier absorption. The connective fibers that support skin undergo changes caused by time, photo-damage and other environmental challenges. This soluble, marine-derived collagen may help reverse these changes and reduce the visible signs of aging. The aging of the skin shifts the balance between collagen production and breakdown leading to wrinkles, facial sag and rough skin texture. Stimulating skin cells to produce collagen can partly reverse this process. Stimulating collagen synthesis in aged skin was shown to reduce wrinkles and improve skin texture. The benefit of stimulating your own collagen production is that collagen is deposited in an orderly, structured manner and that there is no risk of allergy, immune reaction or injection-induced infection. MAGNESIUM ASCORBYL PHOSPHATE & ASCORBYL PALMITATE (Ester C) – "Vitamin C is a multi-tasker," says Los Angeles-based dermatologist Howard Murad, M.D., in his book Wrinkle-Free Forever. First and foremost, it acts as a powerful scavenger of free radicals, seeking out and binding to these potentially dangerous errant molecules created by smoking, exercise, sun and other environmental factors, and even the body's normal chemical reactions that can cause damage and premature aging of the skin. It strengthens capillaries and increases micro-circulation of the skin (thereby increasing the delivery of nutrients necessary for healthy skin) and stimulates healing. Ester C is an extremely stable, absorbable and bioavailable form of Vitamin C. Vitamin C (ascorbic acid) is essential for efficient synthesis of collagen, a key structural protein of the skin. When vitamin C is properly delivered to skin cells, it helps to reduce wrinkles and improve skin texture. Liposomal Delivery of: TISSUE RESPIRATORY FACTOR(SACCHROMYCES CEVERISIAE) – Contained in the yeast extract, it efficiently catches oxygen, which is essential to keep the skin youthful and glowing. Tissue Respiratory Factor, also known as Live Yeast Cell Derivative, is a unique internal moisturizer, which plumps up the skin by increasing moisture uptake from the nascent proteins and increasing oxygen utilization in the skin. Tissue Respiratory Factor has excellent skin revitalizing and soothing properties. • ALPHA LIPOIC – Powerful antioxidant that even supercharges other antioxidants; may help reverse the visible signs of aging by reducing sugar-induced damage to the skin and by enhancing blood flow to the skin, increasing the delivery of nutrients. Prevents glycation – the attachment of sugar to protein. Glycation causes proteins to become “cross-linked.” The support structure of the skin collapses and appears as wrinkles on the surface. ALA helps prevent future cross-linking damage and may even reverse existing damage by improving the metabolism of sugar within the cell, enhancing the body’s natural repair mechanisms and promoting the healthy production of nitric acid, which helps control blood flow – and nutrient delivery – to the skin. • DMAE BITARTRATE – Acts as an antioxidant by helping to stabilize the membranes of skin cells, improves its selective permeability allowing wastes to be expelled more efficiently while allowing nutrients better access to the cell. Protects the cell from free radical damage; firming results are noticed within minutes and continue and improve over time. • VITAMIN A (Retinyl Palmitate) – Vitamin A is used in lubricating creams for its skin-healing and cell-proliferating properties. This fat-soluble vitamin is essential for the maintenance and healing of epithelial tissues, with skin being the largest expanse of epithelial tissue you've got. Can be absorbed through the skin. • VITAMIN E (Tocopheryl Acetate) – Another powerful antioxidant; supports normal formation of muscle and other tissue and is an excellent fat-soluble moisturizer. Helps form normal red blood cells, muscle and other tissues. Protects fat in the body’s normal tissues from abnormal breakdown. Helps slow the aging of skin cells by reducing the production of an enzyme called collagenase, which breaks down collagen, causing the skin to sag and wrinkle according to a study in the journal Free Radical Biology & Medicine. And sun exposure can deplete vitamin E from the skin, making it more vulnerable to sun damage. SODIUM HYDROXYMETHYL GLYCINATE – Derived from the salt of the amino acid Glycine, it is a highly effective, broad-spectrum anti-microbial preservative; a sulfated polysaccharide that has shown promise as a super-moisturizer; promotes tissue growth. 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